1 · Your medications
0 selectedSSRIs
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Mood stabilizers
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Your selected meds and what they act on will appear here.
Which psychedelics work on your meds.
Never stop or skip psychiatric medication to trip. Not medical advice.
Please don't. Interference isn't a clean volume knob: receptor occupancy and enzyme inhibition vary person-to-person and dose-to-dose, so "taking more" can jump from nothing to way too much with no middle setting. And with combos like MDMA + CYP2D6 inhibitors (bupropion, paroxetine, fluoxetine) you get less effect and more toxicity at the same time.
It usually comes on within hours of a serotonergic combination: agitation, confusion, sweating, shivering, diarrhea, tremor, muscle rigidity or twitching (especially clonus in the legs), racing heart, and high fever in severe cases. Mild cases need the drugs stopped and medical advice the same day; fever, rigidity, or confusion means emergency services now — it's treatable, but it can kill if ignored. Don't "wait it out".
Test every batch: reagent kits (Marquis, Ehrlich, Hofmann) cost a few dollars and rule out the most dangerous substitutions — "LSD" that tastes bitter or numbs your mouth should be spit out (NBOMe). Use fentanyl test strips for any powder or pill. Mail-in lab services (DrugsData/EcstasyData, or local drug-checking programs) give exact contents. A test kit is cheaper than an ER visit.
Sober sitter you trust, familiar place, charged phone, no obligations the next day. Start low — tolerance and medication status change response — and don't redose impulsively; wait at least double the expected come-up. Sip water normally (with MDMA don't chug — hyponatremia), stay cool, avoid mixing with alcohol or stimulants, and have a plan for a difficult patch: quiet room, slow breathing, reminder that it passes.
Seizure, trouble breathing, chest pain, temperature above 40°C / 104°F, unresponsiveness, or talk of self-harm: call emergency services immediately and tell paramedics exactly what was taken — their job is to treat, not to judge. While waiting: cool the environment, loosen clothing, put an unconscious breathing person in the recovery position, and stay with them until help arrives.